There appears to be an issue with Microsoft and the IDbCommand net frame which allows token refreshes for Adobe Analytics API tokens. This started about 10 days ago. We have been in contact with Adob...
I've also been seeing this over the past couple weeks. I used to be able to sign back in and it would work. Now I'm getting an error in the service "Failed to update data source credentials: The token provided is not valid for the requested company". I've tried to log in a few different times today and it doesn't work.
Refresh in desktop works for me as well, but that isn't practical to keep data up to date.