Need way to measure/filter with multiple values in multiple columns

This might be a situation where you could employ the "disconnected table trick". I just published a blog article on it here:

https://community.powerbi.com/t5/Community-Blog/Solving-Attendance-with-the-Disconnected-Table-Trick/ba-p/279563

What I am thinking is that you could have a disconnected table of all of your codes and use measures that employ SEARCH or FIND that return true/false based upon whether you can find/search the particular code in each column.

This may not be the way to go.

An alternative and perhaps better approach would be to use Power Query to pivot/unpivot your data such that each item has as many rows as codes. So, you would have something like:

Column, Column1, Column2, Code

blah, blah, blah, PJ

blah, blah, blah, PZ

blah, blah, blah, TC

foo, foo, foo, YT

foo, foo, foo, PJ

foo, foo, foo, TC

Then a standard slicer *should* do the trick.