Multiple Filters (COUNTROWS)

MaleCDEcount = CALCULATE(
                                                 COUNTROWS(Grades),
                                                    FILTER(Grades,Grades[Gender]="M"),
                                                    FILTER(Grades,
                                                         Grades[Grade]="c" || Grades[Grade]="d" || Grades[Grade]="e")

                                                )

My table is named 'Grades' - you will want to change this code to your table name.