Calculate Timeseries relevant for all X Measure Items

I have a big list of Measure Items and need to:

1. Calculate timeseries (e.g. Full PY, PYTD, CYTD) to be relevant for all Measure Items rather than calculating 3 times series for each measure

2. Calculate ratios based on the data model measure items (e.g. Product Margin % Net Sales)

So, how should I build my data model / organize data ?

Currently the raw data contains the following columns:

1. Product Category

2. Measure Item (those from the screenshot above)

3. Year

4. Month

5. Value

I could pivot data with Power Query in any way, of course.

MeasureItems field I would like to use as Slicer too if necessary.

I just don't know how can I include the yellow calculated ratios into the slicer ... 

Thanks!