Create Calculated Column based on multiple values from another table

PBI_Member_01 
Please try the following measure

Falg1 = 
SUMX ( 
    VALUES ( TableA[Profile_ID] ),
    CALCULATE ( 
        VAR TestOrg = CALCULATE ( SELECTEDVALUE ( TableB[TEST_ORG] ), CROSSFILTER ( TableA[ORG_ID], TableB[ORG_ID], BOTH ) ) 
        VAR AProfile = SELECTEDVALUE ( TableA[Profile_ID] )
        VAR CProfiles = CALCULATETABLE ( VALUES ( TableC[Profile_ID] ) )
        VAR DProfiles = CALCULATETABLE ( VALUES ( TableD[Profile_ID] ) )
        VAR Result =
            IF ( 
                TestOrg = "N",
                IF ( 
                    AProfile IN EXCEPT ( CProfiles, DProfiles ),
                    1
                )
            )
        RETURN
            Result
    )
)

You can also place the measure only in the filter pane of the visual and select "Is not blank" then apply the filter. Then it will show like this