I've been getting issues for a while now where the ribbon in desktop will become unresponsive. The only buttons that work are those in the quick access toolbar. This has happened on several versi...
I have this issue too. Windows 7 Enterprise. Just got the October 2018 release and the issue still exists.
I've found it only resolves for me if I open a new PBI instance. Once a new instance is opened the rest have their ribbon unlocked.
Any chance that anyone else with this issue is using a remote desktop? That's the only way I use PBI.