Cannot install On-Premises Gateway

Hi tkrupka 

The issue is probably due to the unique permissions for different folders and something is restricting even the admin to complete the install.

Could you try this:

Find the C:\Users\Default folder, right->Properties -> Security tab -> Advanced -> Change Permissions button -> Check "Replace all child object permission entries with inheritable permission entries from this object"

Security setting to be done

Please try this and try installing the gateway again.