Queries vs single data sheet

Hi all!

I am completely new in the management of this tool; I have been watching tutorials and reading, but in my case I have a single datasheet with all the invoices from 2014 to 2018. I can not connect Power BI because my SQL server is old so the only way that I have to upload the data is by a database from excel. In that way, in the datasheet I have the following items:

1. Invoice code

2. ZIP code

3. Proguct family

4. Product code

5. Quantity of profucts

6. Price of product

7. Total amount of the Invoice

My objective is to create a report which would allow me to watch the profit (Total amount of the Invoice) by product family  YTD and YTY. And also to include the objectives.

I was wondering if I should create different queries with all the infomation of the products, dates, zones, and invoices and it would be easer tu manage my DATA. 

Thank you,