Distinct Count

You can do this with a simple CALCULATE+ DISTINCTCOUNT.

If you want the distinct count of rows where LAR = "ZPROG001" and AES = 10 or 11, try:

meas_Count_LAR_AES =
CALCULATE(
DISTINCTCOUNT(YourTable[YourRowID]),
YourTable[LAR] = "ZPROG001",
YourTable[AES] IN { 10, 11 }
)

Replace YourTable with your table name and YourRowID with a unique row column.

If LAR is already unique per row, you can also distinct-count LAR directly:

meas_Count_LAR_AES =
CALCULATE(
DISTINCTCOUNT(YourTable[LAR]),
YourTable[LAR] = "ZPROG001",
YourTable[AES] IN { 10, 11 }
)