Filter two columns together

Hi Py0809 ,

I updated my sample pbix file(see the attachment), please find the details in it.

1. Create the measures as below

Region Flag = 
VAR _fregion =
    SELECTEDVALUE ( 'Fact'[From Region] )
VAR _tregion =
    SELECTEDVALUE ( 'Fact'[To Region] )
VAR _regions =
    ALLSELECTED ( 'Dim_Region'[Region] )
RETURN
    IF (
        HASONEFILTER ( Dim_Region[Region] ),
        IF ( _fregion IN _regions || _tregion IN _regions, 1, 0 ),
        1
    )

Subregion Flag = 
VAR _fsregion =
    SELECTEDVALUE ( 'Fact'[From Subregion] )
VAR _tsregion =
    SELECTEDVALUE ( 'Fact'[To Subregion] )
VAR _subregions =
    ALLSELECTED ( 'Dim_Subregion'[Subregion] )
RETURN
    IF (
        HASONEFILTER ( Dim_Subregion[Subregion] ),
        IF ( _fsregion IN _subregions || _tsregion IN _subregions, 1, 0 ),
        1
    )

Site Flag = 
VAR _fsite =
    SELECTEDVALUE ( 'Fact'[From Site] )
VAR _tsite =
    SELECTEDVALUE ( 'Fact'[To Site] )
VAR _sites =
    ALLSELECTED ( 'Dim_Site'[Site] )
RETURN
    IF (
        HASONEFILTER ( 'Dim_Site'[Site] ),
        IF ( _fsite IN _sites || _tsite IN _sites, 1, 0 ),
        1
    )

2. Create the visual and apply the visual-level filter with the condition (Region Flag is 1, Subregion Flag is 1 and Site is 1)

Best Regards